Optispan CEO Matt Kaeberlein explains how aging affects our risk of disease and why proactive prevention is the 21st century solution to staying healthy.

Check out the links below for further information and/or reading about some of the things we discussed in this podcast episode. Note that we do not necessarily endorse or agree with the content of these readings, but present them as supplementary material that may deepen your understanding of the topic after you listen to our podcast. This list is in no way exhaustive, but it’s a good start!

Longevity and aging

In this 2013 article, Matt describes the geroscience hypothesis, or the idea that age-related diseases such as Alzheimer's disease and cancer share common causal biological mechanisms. He makes the case that interventions targeting these biological mechanisms will have an impact far higher than that of interventions aimed at treating individual diseases, because the biological mechanisms of aging have an impact on the onset and progression of multiple age-related disorders. The paper also discusses model organisms used in geroscience research and the translatability of research involving these model organisms to humans.


Why Is Aging Conserved and What Can We Do about It?

This article describes pathways that influence longevity and appear to be conserved across a range of organisms such as yeast, fruit flies, and mice. It also discusses the cellular processes regulated by these pathways that may modulate health- and lifespan.


Longevity FAQ: A beginner's guide to longevity research

This FAQ provides a high-level introduction to the geroscience field. It describes the goals of research into the biology of aging and core areas of interest within the field, along with interventions that scientists have tested in mice for effects on life- and/or healthspan.