We read every comment you leave on our Youtube channel. For this episode, we pick a few comments that pointed out places where viewers felt we got things wrong and discuss them in order to the record straight and ensure that our channel remains a trustworthy and high-accuracy information source about all things longevity science. Matt and Nick discuss the degradation of rapamycin in the body, how the scientific method really works, allometric scaling, the relevance of facial appearance to biological age, and more.

Check out the links below for further information and/or reading about some of the things we discussed in this podcast episode. Note that we do not necessarily endorse or agree with the content of these readings, but present them as supplementary material that may deepen your understanding of the topic after you listen to our podcast. This list is in no way exhaustive, but it’s a good start!

Complaining About Hype in the Longevity Industry

This blogpost comments on a review by City of Hope Alfred E. Mann Family Foundation Chair of Diabetes and Cancer Metabolism Charles Brenner of the book Lifespan by Harvard genetics professor David Sinclair. Charles' review criticizes David's book using arguments from evolutionary biology, evidence against Sinclair's theories around sirtuin activators and resveratrol, safety data from partial reprogramming experiments on mice, and more.

Plastic Surgery Sees Steady Growth Amidst Economic Uncertainty, American Society of Plastic Surgeons 2023 Procedural Statistics Report Finds

Plastic surgery procedure aimed at improving appearance are on the rise in the United States. These include "minimally invasive" procedures such as microdermabrasion, chemical peels, and Botox, which consumers typically use to look younger. Neuromodulator injections such as Botox, hyaluronic acid fillers, and skin resurfacing procedures such as lasers took the top three spots for the most procedures performed in 2023. The age groups 20-29 and 30-39 both saw increases in Botox use of over 8 percent.

Abdominal fat analyzed by DEXA scan reflects visceral body fat and improves the phenotype description and the assessment of metabolic risk in mice

This study found a high correlation between visceral fat content measured by DEXA scans and the actual excised visceral fat content of mice, suggesting that DEXA scans are accurate tools for noninvasive fat distribution measurement.

DEXA FAQ

This list of FAQs covers many questions people have about DEXA scans, including how much radiation exposure we receive from DEXA scans, height and weight limits, the safety of DEXA scans for pregnant wome, and more.

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

How might NAD+ precursors such as NMN affect people? This study reported that overweight or obese prediabetic women who had undergone menopause showed improved muscle insulin sensitivity and insulin signaling with NMN supplementation. They also experienced higher levels of downstream muscle NMN metabolites, or nicotinamide byproducts.