Longevity Biologist Reveals Shocking Truth About Fasting, Autophagy & Longevity [Thomas DeLauer]

Fasting is often touted as a powerful tool for health and longevity, but the science behind it is far more complex than most headlines suggest. In this in-depth conversation, Dr. Matt Kaeberlein breaks down how fasting impacts pathways like mTOR and AMPK, how it compares to caloric restriction in animal models, and why the timing of food intake relative to your circadian rhythm can dramatically alter its effects. He explains how different tissues respond to fasting, the nuanced role of autophagy, and why refeeding behavior matters just as much as the fast itself. The discussion also touches on rapamycin, inflammation, and muscle preservation, offering a more sophisticated look at fasting as a targeted intervention rather than a blanket strategy. If you want to truly understand what fasting is doing at the cellular level—and whether it’s worth the hype—this is the video to watch.