In this episode of the Optispan Podcast, Matt sits down with Dr. Kevin White, a concierge medicine physician specializing in preventative and longevity-focused care, to explore the science, misconceptions, and practical applications of testosterone replacement therapy (TRT) for men. They begin by discussing how testosterone levels decline gradually with age in most men, often leading to symptoms like fatigue, poor stress tolerance, decreased lean muscle mass, and reduced libido. Despite its growing popularity, TRT remains surrounded by confusion and stigma—something the conversation aims to clarify.

Dr. White walks listeners through the biomarker panel necessary for an accurate hormone assessment, going beyond total testosterone to include free testosterone, SHBG, albumin, LH, and FSH. These markers help distinguish between primary and secondary hypogonadism and determine whether a patient is an appropriate candidate for TRT. The duo also dives into when lifestyle interventions—like sleep optimization, resistance training, and stress management—can help restore testosterone naturally, especially in younger men.

The conversation shifts to treatment options, comparing injections, topical gels, oral therapies like Jatenzo, and testosterone pellets. Dr. White outlines his preference for low-dose biweekly subcutaneous injections, which better mimic physiological testosterone levels and minimize side effects. They address common concerns such as hair loss, mood changes, cardiovascular risk, and the impact of testosterone on fertility—emphasizing that when prescribed and monitored correctly, TRT is not only safe but potentially beneficial for metabolic health, bone density, cardiovascular risk, and overall quality of life.

Matt and Dr. White also caution against the abuse and overprescription of testosterone, especially by consumer-facing telehealth companies that often skip essential diagnostics and follow-up. They call for more responsible, personalized approaches to TRT that prioritize long-term outcomes and healthspan benefits rather than short-term symptom fixes. They also share insights into polycythemia, the importance of follow-up blood work, and how to distinguish good care from substandard or risky practices.

The episode concludes with a bold yet measured claim: up to 80% of men over 50 may benefit from properly managed TRT. Matt and Dr. White agree that hormone therapy is one of the most impactful tools in the aging toolbox—if used thoughtfully and scientifically. This episode is a must-listen for any man over 40 looking to optimize his health and performance, or anyone navigating the often-confusing world of hormone health.