In this episode, Matt sits down with Dr. Greg Fahy, Chief Scientific Officer at Intervene Immune and the scientist behind the groundbreaking TRIM protocol (Thymus Regeneration, Immunorestoration, and Insulin Mitigation). Dr. Fahy shares how decades of research and a self-experiment led to the first evidence of human thymus regeneration—a milestone with huge implications for reversing immune aging and extending healthspan. He explains the origins of TRIM, including early animal studies showing growth hormone's ability to restore thymic structure and function.

They discuss the metabolic trade-offs of growth hormone, particularly its tendency to raise insulin levels—a pro-aging effect Dr. Fahy mitigated by adding DHEA and metformin. This three-drug combination became the foundation of the TRIM protocol, which he later tested in human trials. Dr. Fahy walks through the science of thymic involution, how it compromises adaptive immunity, and how restoring thymic function may reduce cancer risk, support vaccine responses, and improve systemic health through better immune surveillance.

Matt and Dr. Fahy dive deep into how they assess thymic regeneration using MRI, naïve T-cell populations, and recent thymic emigrant markers. They also explore preliminary results showing improvements in VO2 max, muscle strength, and reductions in blood pressure—suggesting systemic rejuvenation may accompany immune reprogramming. The conversation also touches on the challenges of measuring biological age, the pros and limitations of epigenetic clocks, and what constitutes true aging reversal.

The episode closes with reflections on longevity science, balancing cancer risks with immune health, and next steps for the TRIM protocol—including efforts to reduce cost, improve safety, and test new combinations of interventions. Dr. Fahy also shares hopes for future collaborations and offers a pathway for those interested in participating in upcoming trials. This is a rich, technical, and thought-provoking conversation for anyone interested in immune aging and cutting-edge longevity therapies.